|
KMID : 0545120140240010127
|
|
Journal of Microbiology and Biotechnology
2014 Volume.24 No. 1 p.127 ~ p.131
|
|
|
Lactobacillus plantarum HY7712 Protects Against the Impairment of NK-Cell Activity Caused by Whole-Body γ-Irradiation in Mice
|
|
Lee Ho-Yong
Ahn Young-Tae
Park Se-Hoon
Park Do-Young
Jin Young-Woo
Kim Cha-Soon
Sung Sang-Hyun
Huh Chul-Sung
Kim Dong-Hyun
|
|
|
Abstract
|
|
|
|
While searching for lactic acid bacteria that can restore aging-impaired immune responses, we isolated the Toll-like receptor (TLR) 2/NF-κB-activating strain Lactobacillus plantarum HY7712 from kimchi and investigated its immunomodulating effect in whole-body γ-irradiated mice. Exposure to HY7712 strongly activated NF-κB signaling in RAW264.7 cells, but inhibited lipopolysaccharide-stimulated NF-κB activation. Moreover, HY7712 protected against the downregulation of interferon (IFN)-γ and upregulation of interleukin (IL)-13 caused by γ-irradiation in mice. In mice, γ-irradiation impaired NK-cell activity against YAC-1 tumor cells, but following HY7712 exposure, the activity of NK cells was restored to 91.5% of the level measured in control mice (p < 0.05). These findings suggest that HY7712 activates the TLR2/NF-κB signaling pathway and protects against the impairment of NK-cell activity caused by γ-irradiation or aging.
|
|
|
KEYWORD
|
|
|
Lactobacillus plantarum HY7712, γ-irradiation, aging, NK cell activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|